برهم کنش برخی مواد مغذی با هریک از پلی مورفیسم های CCND2، ZNT8 و MC4R در رابطه با خطر سندرم متابولیک و هر یک از اجزاء آن

Background and purpose: This study aimed at examining the interaction between macronutrients, some micronutrients (magnesium, zinc, iron, calcium, and copper) and CCND2 rs11063069, ZNT8 rs13266634, and MC4R rs12970134 polymorphisms in relation to metabolic syndrome (MetS) and its components. Materials and methods: In this matched nested case-control study, the data for 1634 (817 pairs) case (the new cases of metabolic syndrome) and controls (healthy individuals without metabolic syndrome) were obtained from the Tehran Lipid and Glucose Study. The participants were matched on age, sex, and follow-up years. Dietary intakes were assessed using the Food Frequency Questionnaire (FFQ). The polymorphisms were genotyped by ARMS-PCR. Results: Saturated fatty acid and omega-3 fatty acid could modulate the association of MC4R and ZNT8 variant with MetS, respectively (Pi<0.05). There was a significant interaction between MC4R rs12970134 with total fat intake and abdominal obesity (Pi=0.01). Also, significant interaction was observed between rs13266634 with omega 3 fatty acid and poly-unsaturated fatty acid on the risk of dyslipidemia (high TG and low HDL-C) and high fasting blood glucose, respectively (Pi<0.05). Among micronutrients examined in this study, iron and zinc modified the association of MC4R and ZNT8 variant with abdominal obesity and high fasting blood glucose, respectively (Pi<0.05). Conclusion: According to our findings, low fat diets are recommended in A allele carriers of MC4R rs12970134, while a diet rich in omega-3 and zinc is more appropriate for C allele carriers of ZNT8 rs13266634. &nbsp;